diff --git a/dev-python/neo/ChangeLog b/dev-python/neo/ChangeLog
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index 0000000..649a424
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+++ b/dev-python/neo/ChangeLog
@@ -0,0 +1,4 @@
+*neo-0.10.0 (11 Oct 2021)
+
+  11 Oct 2021;  <chymera@gentoo.org> +metadata.xml, +neo-0.10.0.ebuild:
+  dev-python/neo: new package (DANDI ephys stack)
diff --git a/dev-python/neo/Manifest b/dev-python/neo/Manifest
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+++ b/dev-python/neo/Manifest
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+DIST neo-0.10.0.tar.gz 3282288 SHA256 1063497ebf97545a1f79d5e6174fc7b4b3200cca452c7e4c01dad33b5eca6d36 SHA512 a32103762b307eafbafd0d494907b906bd6203b92ab126b9cb43e54034b86fa0580966e9ce4603e1e4d528bcd3c2d333daca6551c23bfa42e0edf449503a06b0 WHIRLPOOL 3d2f9cb3656ec74514b2e63507709d2e61f7613dd652c7e1e73f2c87192d4f6eba009c3d8314de111d6bfaa1c33d39f3bf41ecfcf46383ac9fc61c1208d07614
diff --git a/dev-python/neo/metadata.xml b/dev-python/neo/metadata.xml
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+++ b/dev-python/neo/metadata.xml
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+<?xml version='1.0' encoding='UTF-8'?>
+<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="person">
+		<email>gentoo@chymera.eu</email>
+		<name>Horea Christian</name>
+	</maintainer>
+	<maintainer type="project">
+		<email>sci@gentoo.org</email>
+		<name>Gentoo Science Project</name>
+	</maintainer>
+	<longdescription lang="en">
+		Neo is a Python package for working with electrophysiology data in Python,
+		together with support for reading a wide range of neurophysiology file
+		formats, including Spike2, NeuroExplorer, AlphaOmega, Axon, Blackrock,
+		Plexon, Tdt, and support for writing to a subset of these formats plus
+		non-proprietary formats including HDF5.
+	</longdescription>
+	<upstream>
+		<remote-id type="github">NeuralEnsemble/python-neo</remote-id>
+	</upstream>
+</pkgmetadata>
diff --git a/dev-python/neo/neo-0.10.0.ebuild b/dev-python/neo/neo-0.10.0.ebuild
new file mode 100644
index 0000000..664200c
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+++ b/dev-python/neo/neo-0.10.0.ebuild
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+# Copyright 2021 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{8..10} )
+inherit distutils-r1
+
+MY_PN="python-neo"
+
+DESCRIPTION="Read and represent a wide range of neurophysiology file formats in Python"
+HOMEPAGE="https://github.com/NeuralEnsemble/python-neo"
+SRC_URI="https://github.com/NeuralEnsemble/python-neo/archive/refs/tags/${PV}.tar.gz -> ${P}.tar.gz"
+
+LICENSE="MIT"
+SLOT="0"
+KEYWORDS="~amd64"
+IUSE="test"
+RESTRICT="test"
+# Numerous test failures, checking with upstream:
+# https://github.com/NeuralEnsemble/python-neo/issues/1037
+
+DEPEND="
+	test? (
+		${RDEPEND}
+		dev-python/scipy[${PYTHON_USEDEP}]
+		dev-python/h5py[${PYTHON_USEDEP}]
+		dev-python/matplotlib[${PYTHON_USEDEP}]
+		dev-python/pillow[${PYTHON_USEDEP}]
+		dev-python/pynwb[${PYTHON_USEDEP}]
+		dev-python/tqdm[${PYTHON_USEDEP}]
+		dev-vcs/datalad
+	)
+"
+# Testing deps also need:
+# igor
+# nixio
+# sonpy
+RDEPEND="
+	dev-python/numpy[${PYTHON_USEDEP}]
+	dev-python/quantities[${PYTHON_USEDEP}]
+"
+BDEPEND=""
+
+S="${WORKDIR}/${MY_PN}-${PV}"
+
+distutils_enable_tests pytest