diff --git a/dev-python/pycryptodomex/ChangeLog b/dev-python/pycryptodomex/ChangeLog
new file mode 100644
index 0000000..4d241fd
--- /dev/null
+++ b/dev-python/pycryptodomex/ChangeLog
@@ -0,0 +1,5 @@
+*pycryptodomex-3.10.4 (27 Sep 2021)
+
+  27 Sep 2021;  <chymera@gentoo.org> +metadata.xml,
+  +pycryptodomex-3.10.4.ebuild:
+  dev-python/pycryptodomex: new package (DANDI stack)
diff --git a/dev-python/pycryptodomex/Manifest b/dev-python/pycryptodomex/Manifest
new file mode 100644
index 0000000..e70c276
--- /dev/null
+++ b/dev-python/pycryptodomex/Manifest
@@ -0,0 +1 @@
+DIST pycryptodomex-3.10.4.tar.gz 3797210 SHA256 acd3498a8ccf8ad20ce7daa5f7f5e6521465eeceb026f28a6adb0228dd9fcc6e SHA512 38a24f8a51c6b3d03e6fc7226921956bfaea4d8839a1e308de417d76931eedc969d913b62d7001bf2116ab613c31e6802194127af25cee2ff83971f871a62111 WHIRLPOOL 60786c71df0a9ca92ebb7a7633676bc6aaf19ebdb69f68a99058252e715462067f53b12cb83277d82d16e3ab4b49c594061e2e0c73a1bddd976b1f51877b626a
diff --git a/dev-python/pycryptodomex/metadata.xml b/dev-python/pycryptodomex/metadata.xml
new file mode 100644
index 0000000..cfee3ba
--- /dev/null
+++ b/dev-python/pycryptodomex/metadata.xml
@@ -0,0 +1,26 @@
+<?xml version='1.0' encoding='UTF-8'?>
+<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="person">
+		<email>gentoo@chymera.eu</email>
+		<name>Horea Christian</name>
+	</maintainer>
+	<maintainer type="project">
+		<email>sci@gentoo.org</email>
+		<name>Gentoo Science Project</name>
+	</maintainer>
+	<longdescription lang="en">
+		PyCryptodome is a self-contained Python package of low-level
+		cryptographic primitives. It is a fork of PyCrypto, and brings
+		numerous enhancements with respect to the official versions of
+		PyCrypto, such as Authenticated encryption modes (GCM, CCM, EAX,
+		SIV, OCB), Accelerated AES on Intel platforms via AES-NI, Elliptic
+		curves cryptography (NIST P-256, P-384 and P-521 curves only),
+		SHA-3 (including SHAKE XOFs), truncated SHA-512 and BLAKE2 hash
+		algorithms, and many more. PyCryptodome is not a wrapper to a
+		separate C library like OpenSSL. To the largest possible extent,
+		algorithms are implemented in pure Python. Only the pieces that
+		are extremely critical to performance (e.g. block ciphers) are
+		implemented as C extensions.
+	</longdescription>
+</pkgmetadata>
diff --git a/dev-python/pycryptodomex/pycryptodomex-3.10.4.ebuild b/dev-python/pycryptodomex/pycryptodomex-3.10.4.ebuild
new file mode 100644
index 0000000..91fda6d
--- /dev/null
+++ b/dev-python/pycryptodomex/pycryptodomex-3.10.4.ebuild
@@ -0,0 +1,34 @@
+# Copyright 1999-2021 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{8..10} )
+
+inherit distutils-r1
+
+DESCRIPTION="Cryptographic library for Python"
+HOMEPAGE="https://www.pycryptodome.org https://pypi.org/project/pycryptodomex/"
+SRC_URI="mirror://pypi/${P:0:1}/${PN}/${P}.tar.gz"
+
+LICENSE="BSD"
+SLOT="0"
+KEYWORDS="~amd64 ~arm ~arm64 ~x86 ~amd64-linux ~x86-linux"
+IUSE="test"
+RESTRICT="test"
+# Numerous tests fail, reported upstream https://github.com/Legrandin/pycryptodome/issues/549
+
+DOCS="README.rst"
+
+RDEPEND=""
+BDEPEND="
+	dev-python/setuptools[${PYTHON_USEDEP}]
+	test? (
+		dev-python/nose[${PYTHON_USEDEP}]
+		dev-python/pytest[${PYTHON_USEDEP}]
+	)"
+
+python_test() {
+	nosetests --verbose || die
+	py.test -v -v || die
+}