diff --git a/dev-python/spikeinterface/ChangeLog b/dev-python/spikeinterface/ChangeLog
new file mode 100644
index 0000000..c0a1167
--- /dev/null
+++ b/dev-python/spikeinterface/ChangeLog
@@ -0,0 +1,5 @@
+*spikeinterface-0.91.0 (13 Oct 2021)
+
+  13 Oct 2021;  <chymera@gentoo.org> +metadata.xml,
+  +spikeinterface-0.91.0.ebuild:
+  dev-python/spikeinterface: new package (DANDI ephys stack)
diff --git a/dev-python/spikeinterface/Manifest b/dev-python/spikeinterface/Manifest
new file mode 100644
index 0000000..5e43b0c
--- /dev/null
+++ b/dev-python/spikeinterface/Manifest
@@ -0,0 +1 @@
+DIST spikeinterface-0.91.0.tar.gz 1226833 SHA256 c6fb8663e327ad4e28f85a5603e592086748bb1c6635bcfadbb34cd6c8e464e8 SHA512 bce2e6919238445d6209112f5ea0177476c5b4b025fbdf02d695bc5da56a9c6404d8d8d8e7dd9f7ec9c702b6752ab12b8b3efebe1e3c0141dd3a03cd16722912 WHIRLPOOL 0f5a1e0bb3ce73f63ba3d8b5e8061477f354363caf5e06e5dfd14f55d6f707edcdc5ace8ca6bb988ed0feb491977f207c083f16736e62f63e8529800c4ee6048
diff --git a/dev-python/spikeinterface/metadata.xml b/dev-python/spikeinterface/metadata.xml
new file mode 100644
index 0000000..b9b71ad
--- /dev/null
+++ b/dev-python/spikeinterface/metadata.xml
@@ -0,0 +1,15 @@
+<?xml version='1.0' encoding='UTF-8'?>
+<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="person">
+		<email>gentoo@chymera.eu</email>
+		<name>Horea Christian</name>
+	</maintainer>
+	<maintainer type="project">
+		<email>sci@gentoo.org</email>
+		<name>Gentoo Science Project</name>
+	</maintainer>
+	<upstream>
+		<remote-id type="github">SpikeInterface/spikeinterface</remote-id>
+	</upstream>
+</pkgmetadata>
diff --git a/dev-python/spikeinterface/spikeinterface-0.91.0.ebuild b/dev-python/spikeinterface/spikeinterface-0.91.0.ebuild
new file mode 100644
index 0000000..dbad22c
--- /dev/null
+++ b/dev-python/spikeinterface/spikeinterface-0.91.0.ebuild
@@ -0,0 +1,55 @@
+# Copyright 2021 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{8..9} )
+# 3.10 missing on numba and spyking-circus
+inherit distutils-r1
+
+DESCRIPTION="A Python-based module for creating flexible and robust spike sorting pipelines."
+HOMEPAGE="https://github.com/SpikeInterface/spikeinterface"
+SRC_URI="https://github.com/SpikeInterface/spikeinterface/archive/refs/tags/${PV}.tar.gz -> ${P}.tar.gz"
+
+LICENSE="MIT"
+SLOT="0"
+KEYWORDS="~amd64"
+IUSE="test"
+RESTRICT="test"
+# Tests fail, checking with upstream
+# https://github.com/SpikeInterface/spikeinterface/issues/307
+
+DEPEND="
+	${RDEPEND}
+	test? (
+		dev-python/loky[${PYTHON_USEDEP}]
+		dev-python/numba[${PYTHON_USEDEP}]
+		dev-python/tridesclous[${PYTHON_USEDEP}]
+		sci-libs/spyking-circus[${PYTHON_USEDEP}]
+		dev-vcs/datalad
+	)
+"
+RDEPEND="
+	dev-python/joblib[${PYTHON_USEDEP}]
+	dev-python/neo[${PYTHON_USEDEP}]
+	dev-python/numpy[${PYTHON_USEDEP}]
+	dev-python/probeinterface[${PYTHON_USEDEP}]
+	dev-python/tqdm[${PYTHON_USEDEP}]
+"
+# also needs:
+# dev-python/PyQt5
+# hbdscan
+# shybird
+# herdingspikes
+# might also need:
+# dev-vcs/git-annex
+# dev-python/matplotlib[${PYTHON_USEDEP}]
+# sci-libs/scikit-learn[${PYTHON_USEDEP}]
+# dev-python/networkx[${PYTHON_USEDEP}]
+# dev-python/pybind11[${PYTHON_USEDEP}]
+# dev-python/pillow[${PYTHON_USEDEP}]
+# dev-python/pandas[${PYTHON_USEDEP}]
+# dev-python/h5py[${PYTHON_USEDEP}]
+BDEPEND=""
+
+distutils_enable_tests pytest