diff --git a/dev-python/ome-zarr/ChangeLog b/dev-python/ome-zarr/ChangeLog
new file mode 100644
index 0000000..8eef6b5
--- /dev/null
+++ b/dev-python/ome-zarr/ChangeLog
@@ -0,0 +1,4 @@
+*ome-zarr-0.2.0 (10 Feb 2022)
+
+  10 Feb 2022;  <chymera@gentoo.org> +metadata.xml, +ome-zarr-0.2.0.ebuild:
+  dev-python/ome-zarr: new package (DANDI stack)  tests fail
diff --git a/dev-python/ome-zarr/Manifest b/dev-python/ome-zarr/Manifest
new file mode 100644
index 0000000..3a770ed
--- /dev/null
+++ b/dev-python/ome-zarr/Manifest
@@ -0,0 +1 @@
+DIST ome-zarr-0.2.0.tar.gz 31269 SHA256 ddded5bfa8a75b0f2e2fd8048353362e89cd00bda4e64a2395ca13055f83356b SHA512 ac2135d9af8ed802e45cc2c8744840d23fd116825c6593c57910537794420bb3b0921153b08e4331d7e9398f7df19531e05c52ed12dfaea9328e159fc21b2b0b WHIRLPOOL 5d8483a607990127c01cb1c5c1b064830c453390661c407959a42f999973724c07248808eb9d7fba8ffed626e6cec350fbc1f099b4b320a8124b3a75ff8d0abe
diff --git a/dev-python/ome-zarr/metadata.xml b/dev-python/ome-zarr/metadata.xml
new file mode 100644
index 0000000..ee9fff5
--- /dev/null
+++ b/dev-python/ome-zarr/metadata.xml
@@ -0,0 +1,15 @@
+<?xml version='1.0' encoding='UTF-8'?>
+<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="person">
+		<email>gentoo@chymera.eu</email>
+		<name>Horea Christian</name>
+	</maintainer>
+	<maintainer type="project">
+		<email>sci@gentoo.org</email>
+		<name>Gentoo Science Project</name>
+	</maintainer>
+	<upstream>
+		<remote-id type="github">ome/ome-zarr-py</remote-id>
+	</upstream>
+</pkgmetadata>
diff --git a/dev-python/ome-zarr/ome-zarr-0.2.0.ebuild b/dev-python/ome-zarr/ome-zarr-0.2.0.ebuild
new file mode 100644
index 0000000..0ce3825
--- /dev/null
+++ b/dev-python/ome-zarr/ome-zarr-0.2.0.ebuild
@@ -0,0 +1,42 @@
+# Copyright 2022 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+MY_PN="${PN}-py"
+
+PYTHON_COMPAT=( python3_{8..10} )
+inherit distutils-r1
+
+DESCRIPTION="Next-generation file format (NGFF) for storing bioimaging data in the cloud"
+HOMEPAGE="https://github.com/ome/ome-zarr-py"
+SRC_URI="https://github.com/ome/ome-zarr-py/archive/refs/tags/v${PV}.tar.gz -> ${P}.tar.gz"
+
+LICENSE="BSD-2"
+SLOT="0"
+KEYWORDS="~amd64"
+IUSE="test"
+# Tests fail:
+# https://github.com/ome/ome-zarr-py/issues/168
+RESTRICT="!test? ( test )"
+
+RDEPEND="
+	dev-python/aiohttp[${PYTHON_USEDEP}]
+	dev-python/dask[${PYTHON_USEDEP}]
+	dev-python/fsspec[${PYTHON_USEDEP}]
+	dev-python/numpy[${PYTHON_USEDEP}]
+	dev-python/quantities[${PYTHON_USEDEP}]
+	dev-python/requests[${PYTHON_USEDEP}]
+	dev-python/toolz[${PYTHON_USEDEP}]
+	dev-python/zarr[${PYTHON_USEDEP}]
+	sci-libs/scikit-image[${PYTHON_USEDEP}]
+"
+DEPEND="
+	test? (
+		${RDEPEND}
+	)
+"
+
+S="${WORKDIR}/${MY_PN}-${PV}"
+
+distutils_enable_tests pytest